PD 142505-0028
PD 142505-0028 (or CI-1017) is a functionally M1-selective muscarinic agonist. It rapidly increases glutamate but not aspartate concentrations in the striatum of anesthetized rats. improved spatial memory of hippocampally deficient mice and nbM-lesioned rats at doses of 1.0-3.2 and 0.1-0.3 mg/kg, respectively, while producing parasympathetic side effects only at very high doses (100-178 mg/kg). Additionally, CI-1017 inhibited production of amyloidogenic A beta and increased secretion of soluble APP. Thus, CI-1017, besides treating AD symptomatically, may also retard its progression.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD520 |
| CAS # | 161774-09-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | CI-1017; CI1017; CI 1017; PD-142505-0028; PD42505-0028; PD 142505-0028 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H20N2O6 |
| Exact Mass | 360.1321 |
| Molecular Weight | 360.3612 |
| Elemental Analysis | C, 59.99; H, 5.59; N, 7.77; O, 26.64 |
| IUPAC/Chemical Name | (E)-1-azabicyclo[2.2.1]heptan-3-one O-(3-(3-methoxyphenyl)prop-2-yn-1-yl) oxime oxalate |
| InChi Key | FSSMLDVGDZVSES-XYJRJTJESA-N |
| InChi Code | InChI=1S/C16H18N2O2.C2H2O4/c1-19-15-6-2-4-13(10-15)5-3-9-20-17-16-12-18-8-7-14(16)11-18;3-1(4)2(5)6/h2,4,6,10,14H,7-9,11-12H2,1H3;(H,3,4)(H,5,6)/b17-16-; |
| SMILES Code | COC1=CC(C#CCO/N=C2CN3CCC/2C3)=CC=C1.O=C(O)C(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |