PKC412 (CGP41251, 4'-N-Benzoylstaurosporine, Midostaurin, CAS 120685-11-2), >99%

LC Laboratories' Product Number P-7600 - PKC412 (CGP41251, 4'-N-Benzoylstaurosporine, Midostaurin), >99% - for research use only. The staurosporine analog, PKC412, inhibits a variety of serine/threonine and tyrosine kinases includingg PKC (IC50 = 50 nM), cyclic AMP-dependent protein kinase (IC50 = 2.4 µM), S6 kinase (IC50 = 5.0 µM), and EGFR (epidermal growth factor receptor) tyrosine-kinase activity (IC50 = 3.0 µM). PKC412 inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor in BALB/c 3T3 cells at submicromolar concentrations. PKC412 strongly blocks the proliferation of ras-transformed pancreatic cancer cells (TUC-3) by causing apoptosis and induction of phenotypic reversion. PKC412 suppresses Akt activity by blocking serine phosphorylation in the kinase activation loop and induces apoptosis in myeloma cell lines. PKC412 selectively inhibits T lymphocyte production of TNF-α (tumor necrosis factor - alpha) with an IC50 of 0.5 µM.

• Supplier: LC Laboratories
• Product #: P-7600
• Sku #: P-7600_500mg