YKL-5-124
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101257 |
| CAS # | 1957203-01-8 |
| Pricing | inquire |
| Biological Activity | YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1]. |
| MWt | 515.61 |
| Formula | C₂₈H₃₃N₇O₃ |