Nemifitide Free Base

Nemifitide Free Base is a novel antidepressant drug with a pentapeptide structure similar to that of melanocyte-inhibiting factor and the amino acid sequence 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH₂. It is under development by Tetragenex for the treatment of major depressive disorder.

• Supplier: Ace Therapeutics
• Product #: SMD1020
• CAS #: 173240-15-8 (free base)
• Synonym: Nemifitide Free Base
• Product Category: Lab-use Small Molecule Drugs
• Chemical Formula: C33H43FN10O6
• Exact Mass: 694.3351
• Molecular Weight: 694.77
• Elemental Analysis: C, 57.05; H, 6.24; F, 2.73; N, 20.16; O, 13.82
• IUPAC/Chemical Name: (2S,4R)-N-((S)-1-((2-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)-1-((S)-2-amino-3-(4-fluorophenyl)propanoyl)-4-hydroxypyrrolidine-2-carboxamide
• InChi Key: SGXPTOACEHQGHL-RCNLLYRESA-N
• InChi Code: InChI=1S/C33H43FN10O6/c34-20-9-7-18(8-10-20)12-23(35)32(50)44-17-21(45)14-27(44)31(49)43-25(6-3-11-39-33(37)38)30(48)41-16-28(46)42-26(29(36)47)13-19-15-40-24-5-2-1-4-22(19)24/h1-2,4-5,7-10,15,21,23,25-27,40,45H,3,6,11-14,16-17,35H2,(H2,36,47)(H,41,48)(H,42,46)(H,43,49)(H4,37,38,39)/t21-,23+,25+,26+,27+/m1/s1
• SMILES Code: N[C@H](C(N1C[C@@H](C[C@H]1C(N[C@H](C(NCC(N[C@H](C(N)=O)Cc(c[nH]2)c3c2cccc3)=O)=O)CCCNC(N)=N)=O)O)=O)Cc4ccc(F)cc4
• Appearance: Solid powder
• Purity: >98% (or refer to the Certificate of Analysis)
• Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• Solubility: To be determined
• Shelf Life: >2 years if stored properly
• Drug Formulation: To be determined
• Stock Solution Storage: 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
• HS Tariff Code: 2934.99.9001