RO5203648 HCl
RO5203648 is a TAAR1 partial agonist (Trace amine-associated receptor 1). RO5203648 showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. RO5203648 increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. RO5203648 demonstrated clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1149 |
| CAS # | 1043491-54-8 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | RO5203648; RO-5203648; RO 5203648. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C9H10Cl4N2O |
| Molecular Weight | 303.992 |
| Elemental Analysis | C, 35.56; H, 3.32; Cl, 46.65; N, 9.22; O, 5.26 |
| IUPAC/Chemical Name | (S)-4-(3,4-dichlorophenyl)-4,5-dihydrooxazol-2-amine dihydrochloride |
| InChi Key | ZYORSKYGFHCZDA-YCBDHFTFSA-N |
| InChi Code | InChI=1S/C9H8Cl2N2O.2ClH/c10-6-2-1-5(3-7(6)11)8-4-14-9(12)13-8;;/h1-3,8H,4H2,(H2,12,13);2*1H/t8-;;/m1../s1 |
| SMILES Code | NC1=N[C@@H](C2=CC=C(Cl)C(Cl)=C2)CO1.[H]Cl.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |