Alpelisib, Free Base (BYL-719, CAS 1217486-61-7), >99%

LC Laboratories' Product Number A-4477 - Alpelisib, Free Base (BYL-719, CAS 1217486-61-7), >99% - for research use only. Alpelisib, also known as BYL719, is a potent and selective phosphatidylinositol-3 kinase α inhibitor. It inhibited P110α, p110β, p110δ, and p110γ with IC50 values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibited the Akt phosphorylation with IC50 values of 74 nM in Rat1-myr-p110α cells, 2.2 µM in Rat1-myr-p110β cells, and 1.2 µM in Rat1-myr-p110δ cells. Alpelisib showed dose- and time-dependent inhibition of PI3Kα signaling in vivo and demonstrated robust anti-tumor response and tolerability in PIK3CA-dependent tumor models. mTORC1 inhibition is necessary for sensitivity to PI3K p110α inhibition by alpelisib in PIK3CA-mutant breast cancer. Related CAS numbers: 1584128-91-5 for the hydrochloride salt. Another CAS number previously assigned to BYL-719 free base, namely 1361185-44-5, has been deleted by CAS and is no longer in use.

• Supplier: LC Laboratories
• Product #: A-4477
• Sku #: A-4477_10mg