WAY-181187 HCl
WAY-181187 is a potent and selective 5-HT6 receptor agonist. WAY-181187 possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (WAY-181187: EC50=6.6 nM, Emax=93%). In the rat frontal cortex, acute administration of WAY-181187 (3-30 mg/kg, subcutaneous (s.c.)) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1250 |
| CAS # | 554403-08-6 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | WAY-181187; WAY 181187; WAY181187; WAY-181187 HCl; WAY-181187 hydrochloride |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C15H13ClN4O2S2 |
| Molecular Weight | 380.865 |
| Elemental Analysis | C, 47.30; H, 3.44; Cl, 9.31; N, 14.71; O, 8.40; S, 16.84 |
| IUPAC/Chemical Name | 2-(1-((6-Chloroimidazo(2,1-b)(1,3)thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethylamine hydrochloride |
| InChi Key | YWNBHKWSECANPP-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C15H13ClN4O2S2.ClH/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20;/h1-4,7-9H,5-6,17H2;1H |
| SMILES Code | NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |