SEC inhibitor KL-1
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-122720-25 mg |
| CAS # | 900308-84-1 |
| Pricing | 25 mg, USD $500.0 |
| Synonyms | KL-1 |
| MWt | 345.78 |
| Formula | C₁₈H₁₆ClNO₄ |
| Biological Activity | SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1]. |
| Purity | 99.67% |