JM-6
JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO). It could increase kynurenic acid levels and reduces extracellular glutamate in the brain. It prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease.. It also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease. It also plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including Alzheimer's and Huntington's diseases.
Supplier | BOC Sciences |
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Product # | 1008119-83-2 |
Pricing | Inquire |
Cas | 1008119-83-2 |
Molecular Weight | 518.60 |
Molecular Formula | C23H26N4O6S2 |
Canonical SMILES | COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=C(S2)CN3CCCCC3)C4=CC(=CC=C4)[N+](=O)[O-])OC |