AMI-1
AMI-1 is a cell permeable inhibitor which inhibits protein arginine N-methyltransferase (PRMT) activity with IC50 of 8.81 µM for PRMT1 and IC50 of 3.04 µM for Hmt1p in vitro. MI-1 does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site and exhibits minimal effects on both SET (Sub39H1, Suv39H2, SET7) and non-SET (DOT1) lysine N-methyltransferases. Furthermore, AMI-1 prevents in vivo arginine methylation of cellular proteins and can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, thus operating as a brake on certain hormone actions.
| Supplier | BOC Sciences |
|---|---|
| Product # | 134-47-4 |
| Pricing | Inquire |
| Cas | 134-47-4 |
| Molecular Weight | 504.49 |
| Molecular Formula | C21H16N2O9S2 |
| Canonical SMILES | O=C(NC1=CC2=CC(S(=O)(O)=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)(O)=O)=CC(O)=C4C=C3 |