p16 INK4A (E6N8P) Rabbit Antibody

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Supplier CD BioSciences
Product # AMA-0158
Pricing 100 μL, Inquire
Product Category Antibodies
Application WB, IP, IF
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50); Immunofluorescence (1:800-1:3200)
Reactivity Human
Host Rabbit
Source/Isotype Rabbit IgG
MW (Target) 16 kDa
Storage Store at -20°C.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly139 of human p16 INK4A protein.
Background
  • Members of the INK4 family of cyclin dependent kinase inhibitors include p16 INK4A, p15 INK4B, p18 INK4C, and p19 INK4D. The INK4 family members inhibit cyclin dependent kinases 4 and 6 (CDK4 and CDK6), causing cell cycle arrest in G1 phase. The INK4A-ARF-INK4B locus on chromosome 9p21, frequently lost in human cancer, encodes the INK4 family members p16 INK5A and p15 INK4B, as well as the unrelated protein, ARF.
  • p16 INK4A expression, typically repressed in the absence of stress, is thought to drive cells into senescence, and p16 INK4A expression is a commonly used marker of senescent cells. p16 INK4A protein expression is often altered in human cancer, and high expression is currently used as a predictive biomarker in cervical cancer.
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