anti-CD3E immunotoxin UCHT1 (IgG)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-CD3E monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells which carry a CD3 epitope. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L049R |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | CD3E |
| Species Reactivity | Human |