SB-228357
SB-228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). SB-228357 displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1170 |
| CAS # | 181629-93-6 |
| Pricing | Customizable size, Inquiry |
| Synonym | SB-228357; SB 228357; SB228357. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C22H17F4N3O2 |
| Exact Mass | 431.1257 |
| Molecular Weight | 431.39 |
| Elemental Analysis | C, 61.25; H, 3.97; F, 17.62; N, 9.74; O, 7.42 |
| IUPAC/Chemical Name | 1H-Indole-1-carboxamide, N-(3-fluoro-5-(3-pyridinyl)phenyl)-2,3-dihydro-5-methoxy-6-(trifluoromethyl)- |
| InChi Key | RRJLJKRFFRZRAF-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30) |
| SMILES Code | O=C(N1CCC2=C1C=C(C(F)(F)F)C(OC)=C2)NC3=CC(C4=CC=CN=C4)=CC(F)=C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |