PT 1

PT 1 is an AMPK (AMP-activated protein kinase) activator that stimulates AMPK heterotrimer (α1β1γ1) activity (EC50=0.3 μM). PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes. It stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes.

• Supplier: BOC Sciences
• Product #: 331002-70-1
• Cas: 331002-70-1
• Molecular Weight: 497.91
• Molecular Formula: C23H16ClN3O6S
• Canonical SMILES: CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=O)N=C(S3)NC4=CC(=C(C=C4)Cl)C(=O)O)[N+](=O)[O-])C