N-piperidine Ibrutinib hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-130983-10 mM * 1 mL |
| CAS # | 2231747-18-3 |
| Pricing | 10 mM * 1 mL, USD $220.0 |
| Biological Activity | N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively[1]. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2]. |
| MWt | 422.91 |
| Formula | C₂₂H₂₃ClN₆O |