Decitabine, Free Base (5-aza-CdR, 5-aza-dC, AzadC, 5-Aza-2'-deoxycytidine, 5-Azadeoxycytidine, DAC, Dacogen, Dezocitidine, 2'-Deoxy-5-azacytidine, NSC-127716, CAS 2353-33-5), >99%

LC Laboratories' Product Number D-3899 - Decitabine, Free Base (5-aza-CdR, 5-aza-dC, AzadC, 5-Aza-2'-deoxycytidine, 5-Azadeoxycytidine, DAC, Dacogen, Dezocitidine, 2'-Deoxy-5-azacytidine, NSC-127716, CAS 2353-33-5), >99% - for research use only. Decitabine is a cytosine nucleoside analog and inhibits further DNA methylation after incorporated into DNA. As a consequence, tumor suppressor genes aberrantly silenced after methylation can be reactivated and expressed. Decitabine has shown activity in some hematologic disorders including myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML). Treatment of patients with sickle cell disease (SSD) with subcutaneous decitabine increased fetal hemoglobin (HbF) levels and improved SSD pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity without cytotoxicity. A phase III study demonstrated that decitabine was clinically effective in the treatment of patients with MDS. Decitabine showed durable responses and delayed time to AML transformation/death. Decitabine is the active ingredient in the drug sold under the trade name Dacogen®. This drug is currently approved in at least one country for use in patients with MDS. NOTE: THE DECITABINE FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT DACOGEN®, AND IS NOT FOR HUMAN USE. Other CAS numbers previously assigned to Decitabine, Free Base, namely 105597-46-4 and 123795-43-7, have been deleted by CAS and are no longer in use.

• Supplier: LC Laboratories
• Product #: D-3899
• Sku #: D-3899_1g