phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P. In humans, the enzyme is localized to late endosomal/lysosomal membranes. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis.

• Supplier: Creative Enzymes
• Product #: EXWM-3683