Cerlapirdine hydrochloride
Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. As of 2011, it is in phase II clinical trials, and has demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1463 |
| CAS # | 925447-04-7 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Cerlapirdine hydrochloride; SAM531; SAM 531 SAM-531; PF-05212365; P -05212365; PF05212365; PF-5212365; P -5212365; PF5212365; WAY-262,531; WAY 262,531; WAY262,531 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C22H24ClN3O3S |
| Molecular Weight | 445.96 |
| Elemental Analysis | C, 59.25; H, 5.42; Cl, 7.95; N, 9.42; O, 10.76; S, 7.19 |
| IUPAC/Chemical Name | 1-Propanamine, N,N-dimethyl-3-((3-(1-naphthalenylsulfonyl)-1H-indazol-5- yl)oxy)-, hydrochloride (1:1) |
| InChi Key | RNGAZJUESDPASQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C22H23N3O3S.ClH/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21;/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24);1H |
| SMILES Code | O=S(C1=NNC2=C1C=C(OCCCN(C)C)C=C2)(C3=C4C=CC=CC4=CC=C3)=O.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |