PHCCC
PHCCC is a positive allosteric modulator of mGluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- and NMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficacious mGluR1 antagonist CPCCOEt and was blocked by MSOP, a group-III mGluR antagonist. Our data provide evidence for a novel pharmacological site on mGluR4, which may be used as a target-site for therapeutics.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1108 |
| CAS # | 179068-02-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | PHCCC |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H14N2O3 |
| Exact Mass | 294.1004 |
| Molecular Weight | 294.31 |
| Elemental Analysis | C, 69.38; H, 4.79; N, 9.52; O, 16.31 |
| IUPAC/Chemical Name | (E)-7-(hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide |
| InChi Key | FPXPIEZPAXSELW-CYVLTUHYSA-N |
| InChi Code | InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15- |
| SMILES Code | O=C(C1(C2)C2/C(C3=C(O1)C=CC=C3)=N\O)NC4=CC=CC=C4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |