Pavinetant
Pavinetant, also known as MLE-4901, AZD-4901, AZ-12472520, and AZD-2624, is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which is under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS). It was also under investigation for the treatment of schizophrenia, but development was discontinued for this indication due to lack of effectiveness. As of 2017, the drug is in phase II clinical trials for hot flashes and PCOS.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1612 |
| CAS # | 941690-55-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | AZD-2624; AZD2624; AZD 2624; MLE-4901; MLE4901; MLE 4901; AZD-4901; AZD 4901; AZD4901; AZ-12472520; AZ 12472520; AZ12472520; pavinetant; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H25N3O3S |
| Exact Mass | 459.1617 |
| Molecular Weight | 459.564 |
| Elemental Analysis | C, 67.95; H, 5.48; N, 9.14; O, 10.44; S, 6.98 |
| IUPAC/Chemical Name | (S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide |
| InChi Key | QYTBBBAHNIWFOD-NRFANRHFSA-N |
| InChi Code | InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1 |
| SMILES Code | O=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |