LDN-193189
LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For animal testing, the water-soluble S7507 LDN-193189 2HCl is recommended.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S2618 |
| Sku # | S2618-5mg |
| Pricing | 5mg, $170.00 |
Citations for this product:
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Shear stress and very low levels of ligand synergize to activate ALK1 signaling in endothelial cellsbioRxiv - Cell Biology 2023Quote: ... The following concentrations and incubation times were utilized for each chemical: LDN193189 (1 µM; Cat: S2618, Selleck Chemicals, Houston, TX USA) and Y27632 (10 µM ...
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bioRxiv - Neuroscience 2023Quote: ... 100nM LDN-193189 (Selleck Chemicals, #S2618), and 2nM XAV939 (Tocris Bioscience ...
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bioRxiv - Neuroscience 2023Quote: ... cells were fed with E6+100nM LDN193189 (Selleck Chemicals, S2618)+10 µM SB431542 +2 µM XAV939 (TOCRIS ...