Tubulysin D
Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. It displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range.
| Supplier | BOC Sciences |
|---|---|
| Product # | BBF-02728 |
| Pricing | Inquire |
| Cas | 309935-57-7 |
| Molecular Weight | 828.07 |
| Molecular Formula | C43H65N5O9S |
| Canonical SMILES | CCC(C)C(C(=O)N(COC(=O)CC(C)C)C(CC(C1=NC(=CS1)C(=O)NC(CC2=CC=CC=C2)CC(C)C(=O)O)OC(=O)C)C(C)C)NC(=O)C3CCCCN3C |