Trofosfamide-[d4]
Labelled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis.
| Supplier | BOC Sciences |
|---|---|
| Product # | BLP-007545 |
| Pricing | Inquire |
| Cas | 1189884-36-3 |
| Molecular Weight | 327.61 |
| Molecular Formula | C9H14D4Cl3N2O2P |
| Canonical SMILES | C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl |