Bnip3L/Nix Antibody
Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3α, and Nix (for Nip3-like protein X). Bnip3L/Bnip3α/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes supression by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The message RNA of Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins.
| Supplier | Creative Biogene |
|---|---|
| Product # | PBCA1020 |
| Pricing | Inquiry |
| Isotype | Rabbit IgG |
| Research Area | Antibody |
| Antibody Target | Bnip3L/Nix |
| Antibody Type | Polyclonal |
| Application | WB, IHC |
| Formulation | 0.5 mg/ml of antibody in PBS, pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal |
| Appearance | Liquid |
| Host | Rabbit |
| Species Reactivity | Human, Mouse |
| Usage Statement | Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses. |