CDK12-IN-2
CDK12-IN-2, a potent and selective nanomolar CDK12 inhibitor (IC50 = 52 nM) with good physicochemical properties, inhibits phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II, and can be used as an excellent chemical probe for the study of CDK12 function. It is also a strong CDK13 inhibitor because CDK13 is the closest homologue of CDK12. It shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2244987-03-7 |
| Pricing | Inquire |
| Cas | 2244987-03-7 |
| Molecular Weight | 532.64 |
| Molecular Formula | C32H32N6O2 |
| Canonical SMILES | CN1C=C(C=CC1=O)C2=CC=C(C=C2)N(C3CCC(CC3)NC4=NC=C(C=C4)C#N)C(=O)NCC5=CC=CC=C5 |