Anhydroleucovorin
Anhydroleucovorin, also known as 5,10-Methenyltetrahydrofolate (5,10-CH=THF), is a form of tetrahydrofolate that is an intermediate in metabolism. 5,10-CH=THF is a coenzyme that accepts and donates methenyl (CH=) groups. It is produced from 5,10-methylenetetrahydrofolate by either a NAD+ dependent methylenetetrahydrofolate dehydrogenase, or a NADP+ dependent dehydrogenase. It can also be produced as an intermediate in histidine catabolism, by formiminotransferase cyclodeaminase, from 5-formiminotetrahydrofolate. 5,10-CH=THF is a substrate for methenyltetrahydrofolate cyclohydrolase, which converts it into 10-formyltetrahydrofolate.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1374 |
| CAS # | 7444-29-3 |
| Pricing | Customizable size, Inquiry |
| Synonym | Anhydroleucovorin; 5,10-Methenyltetrahydrofolate; 5,10-CH=THF, |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H21N7O6 |
| Exact Mass | 455.1553 |
| Molecular Weight | 455.431 |
| Elemental Analysis | C, 52.75; H, 4.65; N, 21.53; O, 21.08 |
| IUPAC/Chemical Name | (S)-2-(4-((R)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8-ium-8-yl)benzamido)-4-carboxybutanoate |
| InChi Key | MEANFMOQMXYMCT-OLZOCXBDSA-N |
| InChi Code | InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/t12-,13+/m1/s1 |
| SMILES Code | O=C1C2=C(NC(N)=N1)NC[C@]3(N2C=[N+](C3)C4=CC=C(C=C4)C(N[C@@H](CCC(O)=O)C([O-])=O)=O)[H] |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |