COTI-2
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-19896-10 mg |
| CAS # | 1039455-84-9 |
| Pricing | 10 mg, USD $125.0 |
| Biological Activity | COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation[1][2][3]. |
| Purity | 98.96% |
| MWt | 366.48 |
| Formula | C₁₉H₂₂N₆S |