Vercirnon
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15724-5 mg |
| CAS # | 698394-73-9 |
| Pricing | 5 mg, USD $420.0 |
| Synonyms | GSK-1605786; CCX282-B; Traficet-EN |
| MWt | 444.93 |
| Formula | C₂₂H₂₁ClN₂O₄S |
| Biological Activity | Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively[1]. |
| Purity | 98.19% |