PF-543 hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15425B |
| CAS # | 1706522-79-3 |
| Pricing | inquire |
| Biological Activity | PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy[1][2][3]. |
| Synonyms | Sphingosine Kinase 1 Inhibitor II hydrochloride |
| MWt | 502.07 |
| Formula | C₂₇H₃₂ClNO₄S |