Glyoxalase II (Glx II), human recombinant
The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.
| Supplier | CD BioSciences |
|---|---|
| Product # | APE-023 |
| Pricing | , Inquire |
| Product Category | Proteins/Enzymes |
| Gene ID | 3029 |
| Alternate Name | Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2 |
| Molecular Weight | 32.4 kDa |
| Appearance | Liquid |
| Storage Conditions | -20°C |
| Gene Symbol | HAGH |
| Source | E. coli |
| Physical Form Description | 30% glycerol, 50 mM Tris pH 7.4 and 150 mM NaCl |
| Purity by SDS-PAGE | ≥90% |