GRK2-IN-1

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Supplier MedChemExpress
Product # HY-109562
CAS # 2055990-90-2
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Biological Activity
  • GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).
  • GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].
MWt 452.48
Formula C₂₄H₂₅FN₄O₄
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