ICI-118551 HCl
ICI-118551, also known as ICI-118,551 and ICI 111581, is a selective beta-2 (β2) adrenergic receptor antagonist. ICI-118551 binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008. ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, as few other specific antagonists for this receptor are known.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD217 |
| CAS # | 72795-01-8 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | ICI 111581; ICI-111581; ICI111581; ICI118551; ICI 118551; ICI-118551; ICI118,551; ICI 118,551; ICI-118,551; ICI-118551 HCl. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H28ClNO2 |
| Molecular Weight | 313.87 |
| Elemental Analysis | C, 65.06; H, 8.99; Cl, 11.29; N, 4.46; O, 10.19 |
| IUPAC/Chemical Name | (2R,3R)-3-(isopropylamino)-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride |
| InChi Key | KBXMBGWSOLBOQM-CACIRBSMSA-N |
| InChi Code | InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16+;/m1./s1 |
| SMILES Code | C[C@@H](NC(C)C)[C@@H](O)COC1=CC=C(C)C2=C1CCC2.[H]Cl |
| Appearance | white to off-white solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |