Sitravatinib

Supplier MedChemExpress
Product # HY-16961-10 mg
CAS # 1123837-84-2
Pricing 10 mg, USD $120.0
Synonyms MGCD516; MG-516
MWt 629.68
Formula C₃₃H₂₉F₂N₅O₄S
Biological Activity Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2].
Purity 99.85%
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