Sitravatinib
Supplier | MedChemExpress |
---|---|
Product # | HY-16961-10 mg |
CAS # | 1123837-84-2 |
Pricing | 10 mg, USD $120.0 |
Synonyms | MGCD516; MG-516 |
MWt | 629.68 |
Formula | C₃₃H₂₉F₂N₅O₄S |
Biological Activity | Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2]. |
Purity | 99.85% |