RU 43044
RU 43044 is a selective glucocorticoid receptor antagonist that has shown an antidepressant-like effect. Subchronic treatment with RU-43044 decreased the immobility time in the forced swim test in chronic corticosterone-treated and isolation-reared mice, but not the control mice. Chronic corticosterone decreased the levels of cortical glucocorticoid receptors and stress-induced increases in plasma corticosterone levels, and blocked the response of plasma corticosterone to dexamethasone, while isolation rearing did not cause any changes in the glucocorticoid receptor system. Subchronic RU-43044 reversed the enhanced release of dopamine in the prefrontal cortex of chronic corticosterone-treated and isolation-reared mice.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1165 |
| CAS # | 136959-96-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | RU 43044; RU-43044; RU43044; RU-044; RU044; RU-044; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C29H34O2 |
| Exact Mass | 414.2559 |
| Molecular Weight | 414.58 |
| Elemental Analysis | C, 84.02; H, 8.27; O, 7.72 |
| IUPAC/Chemical Name | (8S,10R,13S,14R,17R)-17-hydroxy-13-methyl-10-(4-methylbenzyl)-17-(prop-1-yn-1-yl)-1,2,6,7,8,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| InChi Key | NSUUUQRFPXZFLI-OWWDREAESA-N |
| InChi Code | InChI=1S/C29H34O2/c1-4-14-29(31)17-13-25-24-10-9-22-18-23(30)11-16-28(22,26(24)12-15-27(25,29)3)19-21-7-5-20(2)6-8-21/h5-8,12,18,24-25,31H,9-11,13,15-17,19H2,1-3H3/t24-,25+,27-,28+,29+/m0/s1 |
| SMILES Code | O=C1CC[C@]2(CC3=CC=C(C)C=C3)C4=CC[C@]5(C)[C@](C#CC)(O)CC[C@]5([H])[C@]4([H])CCC2=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |