Ciproxifan maleate
Ciproxifan, also known as FUB-359, is an extremely potent histamine H3 inverse agonist/antagonist. Ciproxifan produces wakefulness and attentiveness in animal studies, and produced cognitive enhancing effects without prominent stimulant effects at relatively low levels of receptor occupancy, and pronounced wakefulness at higher doses. It has therefore been proposed as a potential treatment for sleep disorders such as narcolepsy and to improve vigilance in old age, particularly in the treatment of conditions such as Alzheimer's disease. It also potentiated the effects of antipsychotic drugs, and has been suggested as an adjuvant treatment for schizophrenia.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD459 |
| CAS # | 184025-19-2 (maleate) |
| Pricing | Customizable size, Inquiry |
| Synonym | FUB-359; FUB 359; FUB359; Ciproxifan. Ciproxifan maleate |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H22N2O6 |
| Exact Mass | 270.1368 |
| Molecular Weight | 386.404 |
| Elemental Analysis | C, 62.17; H, 5.74; N, 7.25; O, 24.84 |
| IUPAC/Chemical Name | Cyclopropyl-(4-(3-1H-imidazol-4-yl)propyloxyphenyl)ketone maleate |
| InChi Key | RLQFKEYRALXXEJ-BTJKTKAUSA-N |
| InChi Code | InChI=1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| SMILES Code | O=C(C1CC1)C2=CC=C(OCCCC3=CNC=N3)C=C2.O=C(O)/C=C\C(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |