RAGE, human recombinant
Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
| Supplier | CD BioSciences |
|---|---|
| Product # | APE-048 |
| Pricing | , Inquire |
| Product Category | Proteins/Enzymes |
| Gene ID | 117 |
| Alternate Name | Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER |
| Molecular Weight | 35 kDa |
| Appearance | Lyophilized protein |
| Storage Conditions | -20°C |
| Gene Symbol | AGER |
| Source | Human cells |
| Physical Form Description | Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH7.2. |
| Purity by SDS-PAGE | ≥95% |
| Amino Acid Sequence | Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus. |