Gomisin D
Gomisin D is a lignan that has been found in S. chinensis and has diverse biological activities, including enzyme inhibitory and antioxidant properties. It inhibits acetylcholinesterase (AChE) with an IC50 value of 7.84 µM. Gomisin D scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals. It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A3 by 89.9 and 83.1%, respectively, when used at a concentration of 100 µM. It is selective for UGT1A1 and UGT1A3 over other UGT isoforms at 100 µM.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD231 |
| CAS # | 60546-10-3 |
| Pricing | Customizable size, Inquiry |
| Synonym | Gomisin D; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C28H34O10 |
| Exact Mass | 530.2152 |
| Molecular Weight | 530.57 |
| Elemental Analysis | C, 63.39; H, 6.46; O, 30.15 |
| IUPAC/Chemical Name | (6R,7R,10S,18S,19S)-7,19-dihydroxy-12,13,14-trimethoxy-6,7,18,19-tetramethyl-6,7-dihydro-10H-10,15-propano[1,3]dioxolo[4',5':5,6]benzo[1,2-g]benzo[i][1,6]dioxacycloundecin-8(5H)-one |
| InChi Key | VLLFEMVDMFTBHG-KMIFWYFFSA-N |
| InChi Code | InChI=1S/C28H34O10/c1-13-8-15-9-18-22(37-12-36-18)24-19(15)20-16(10-17(32-5)21(33-6)23(20)34-7)25(27(13,3)30)38-26(29)28(4,31)14(2)11-35-24/h9-10,13-14,25,30-31H,8,11-12H2,1-7H3/t13-,14+,25-,27-,28+/m0/s1 |
| SMILES Code | COC1=CC2=C(C3=C(C[C@@H]([C@](O)([C@]2(OC([C@@]4(O)C)=O)[H])C)C)C=C5C(OCO5)=C3OC[C@H]4C)C(OC)=C1OC |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |