Caudatin
Caudatin is a C-21 steroid that has been found in C. auriculatum and has anticancer activity. It is cytotoxic to SMMC-7721, MCF-7, and HeLa cells (IC50s = 24.95, 65.82, and 247.54 µM, respectively). Caudatin (50-300 µM) induces apoptosis in and inhibits mammosphere formation by MDA-MB-231 breast cancer cells, as well as decreases the number of cancer stem cells (CSCs) in the MDA-MB-231 cell population. In vivo, caudatin (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD706 |
| CAS # | 38395-02-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | Caudatin; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C28H42O7 |
| Exact Mass | 490.2931 |
| Molecular Weight | 490.637 |
| Elemental Analysis | C, 68.55; H, 8.63; O, 22.83 |
| IUPAC/Chemical Name | (3S,8S,9R,10R,12R,13S,14R,17S)-17-acetyl-3,8,14,17-tetrahydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl (E)-3,4-dimethylpent-2-enoate |
| InChi Key | VWLXIXALPNYWFH-UXGQNDOZSA-N |
| InChi Code | InChI=1S/C28H42O7/c1-16(2)17(3)13-23(31)35-22-15-21-24(5)9-8-20(30)14-19(24)7-10-27(21,33)28(34)12-11-26(32,18(4)29)25(22,28)6/h7,13,16,20-22,30,32-34H,8-12,14-15H2,1-6H3/b17-13+/t20-,21+,22+,24-,25+,26+,27-,28+/m0/s1 |
| SMILES Code | C[C@@]12[C@@](CC[C@]2(C(C)=O)O)(O)[C@@]3(O)[C@]([H])(C[C@H]1OC(/C=C(C(C)C)\C)=O)[C@]4(C)C(C[C@@H](O)CC4)=CC3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |