Itasetron
Itasetron is a potent 5HT-3 receptor antagonist. Itasetron hydrochloride is a new 5-hydroxytryptamine3 (5-HT3) antagonist with potent antiemetic properties. It is more potent than ondansetron in animal models and in early clinical studies it demonstrates a long half-life and does not undergo hepatic biotransformation before elimination. itasetron hydrochloride is effective in the dose range 35-280 microg/kg in preventing cisplatin-induced emesis.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD200 |
| CAS # | 123258-84-4 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | Itasetron; DAU 6215CL; DAU6215CL; U 98079A; U-98079A; UNII-00S0D0OEKR; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H20N4O2 |
| Exact Mass | 300.1586 |
| Molecular Weight | 300.36 |
| Elemental Analysis | C, 63.98; H, 6.71; N, 18.65; O, 10.65 |
| IUPAC/Chemical Name | 1H-Benzimidazole-1-carboxamide, 2,3-dihydro-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo, endo- |
| InChi Key | RWXRJSRJIITQAK-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C16H20N4O2/c1-19-11-6-7-12(19)9-10(8-11)17-15(21)20-14-5-3-2-4-13(14)18-16(20)22/h2-5,10-12H,6-9H2,1H3,(H,17,21)(H,18,22) |
| SMILES Code | O=C(N1C2=CC=CC=C2NC1=O)NC3CC(N4C)CCC4C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |