Antide acetate
Antide acetate is a third generation gonadotropin-releasing hormone receptor antagonist. It inhibits GnRH-induced secretion of luteinizing hormone, follicle-stimulating hormone, and gonadotropin in isolated rat pituitary cells when used at concentrations ranging from 0.001 to 1,000 nM but does not induce histamine release in isolated rat mast cells. Antide acetate reduces serum LH and FSH levels in orchidectomized cynomolgus monkeys. It inhibits ovulation in rats when administered at a dose of 2 µg/animal. Antide acetate reduces the intensity and duration of catalepsy induced by haloperidol in rats.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD089 |
| CAS # | 625092-10-6 |
| Pricing | Customizable size, Inquiry |
| Synonym | Antide acetate; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C84H112ClN17O16 |
| Exact Mass | 1649.8161 |
| Molecular Weight | 1651.373 |
| Elemental Analysis | C, 61.10; H, 6.84; Cl, 2.15; N, 14.42; O, 15.50 |
| IUPAC/Chemical Name | N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-amino-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotinamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)nicotinamide acetate |
| InChi Key | RHBDDEILKDGLGU-OHURHHEJSA-N |
| InChi Code | InChI=1S/C82H108ClN17O14.C2H4O2/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55;1-2(3)4/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111);1H3,(H,3,4)/t52-,62+,63-,64+,65+,66-,67-,68-,69+,70+;/m1./s1 |
| SMILES Code | ClC1=CC=C(C[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@@H](C(N)=O)C)=O)CCC2)=O)CCCCNC(C)C)=O)CC(C)C)=O)CCCCNC(C3=CN=CC=C3)=O)=O)CCCCNC(C4=CN=CC=C4)=O)=O)CO)=O)CC5=CN=CC=C5)=O)NC([C@@H](CC6=CC7=C(C=C6)C=CC=C7)NC(C)=O)=O)C=C1.O=C(O)C |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |