AG-490

AG490 is a JAK-2-specific inhibitor that inhibits the phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], thereby reducing the invasion and adhesion potential of malignant cells. Hematopoietic system tumors c-Kit+, Jak-2+ and non-hematopoietic system tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemotherapy sensitizer AG490, causing programmed cell death.

• Supplier: Alfa Cytology
• Product #: BC0373