Calcitonin human
Calcitonin is a peptide hormone that lowers blood calcium levels and inhibits bone resorption. The binding of human calcitonin to the calcitonin receptor (CTR) is modulated by receptor activity-modifying proteins (RAMPs). Calcitonin binds to CTR2 with IC50 values of 8.5, 6.2, 10.7, and 5.8 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in rabbit aortic endothelial cells (RAECs) expressing CTR2 alone, or co-transfected with RAMP1, 2, or 3 (EC50s = 0.07, 0.08, 0.05, and 0.99 nM, respectively).
| Supplier | BOC Sciences |
|---|---|
| Product # | BAT-010826 |
| Pricing | Inquire |
| Cas | 21215-62-3 |
| Molecular Weight | 3417.84 |
| Molecular Formula | C151H226N40O45S3 |
| Canonical SMILES | NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H](C(C)C)NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@@H]2CCCN2C([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC(CNC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N3)CSSC[C@H](N[H])C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)CC(O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)CC6=CC=CC=C6)=O)CC7=CN=CN7)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O.FC(F)(C(O)=O)F |