| Supplier |
CD BioSciences |
| Product # |
AMA-0628 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP, ChIP
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:100); Chromatin IP (1:100)
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Host |
Rabbit
|
| Gene ID |
9841
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
95 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro569 of human ZBTB24 protein.
|
| Background |
Zinc finger and BTB domain-containing protein 24 (ZBTB24), also called ZNF450, is a DNA-binding protein initially found to be expressed in response to BMP-2 signaling ZBTB24 along with CDCA7 play a role in DNA methylation by recruiting the HELLS chromatin remodeling complex to centromeric satellite repeats Mutations in ZBTB24 are linked to immunodeficiency and centromeric instability, and facial anomalies syndrome type 2 (ICF2) ZBTB24 is recruited to DNA breaks by PARP1 and promotes assembly of the LIG4/XRCC4 complex, resulting in error free non-homologous end joining (NHEJ) ZBTB24 has also been shown to play a role in trophoblast proliferation through the methylation of E-cadherin.
|