D-3263
D-3263 is a TRPM8 agonist ( transient receptor potential melastatin member 8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer.
| Supplier | BOC Sciences |
|---|---|
| Product # | 947257-66-1 |
| Pricing | Inquire |
| Cas | 947257-66-1 |
| Molecular Weight | 373.49 |
| Molecular Formula | C21H31N3O3 |
| Canonical SMILES | CC1CCC(C(C1)C(=O)N2C3=C(C=C(C=C3)OC)N(C2=O)CCN)C(C)C |