Calcium chloride hexahydrate
Calcium chloride occurs as a white or colorless crystalline powder,granules, or crystalline mass, and is hygroscopic (deliquescent).
| Supplier | CD Formulation |
|---|---|
| Product # | PE0387 |
| Pricing | , Inquire for price |
| product1 | Pharmaceutical Excipients |
| Molecular Formula | CaCl2ยท 6H2O |
| Molecular Weight | 219.1 (for hexahydrate) |
| Applications | The main applications of calcium chloride as an excipient relate to its dehydrating properties and, therefore, it has been used as an antimicrobial preservative, as a desiccant, and as an astringent in eye lotions. Therapeutically, calcium chloride injection 12% (as the dihydrate form) is used to treat hypocalcemia. |
| Safety | Calcium chloride is used in topical, ophthalmic, and injection preparations. The pure form of calcium chloride is toxic by intravenous, intramuscular, intraperitoneal, and subcutaneous routes, and moderately toxic by ingestion, causing stomach and heart disturbances. It is a severe eye irritant and can cause dermatitis. LD50 (mouse, IP): 0.21 g/kg; LD50 (mouse, IV): 0.042 g/kg; LD50 (mouse, oral): 1.94 g/kg; LD50 (mouse, SC): 0.82 g/kg; LD50 (rat, IM): 0.025 g/kg; LD50 (rat, IP): 0.26 g/kg; LD50 (rat, oral): 1.0 g/kg; LD50 (rat, SC): 2.63 g/kg |
| Incompatibilities | Calcium chloride is incompatible with soluble carbonates, phosphates, sulfates, and tartrates.It reacts violently with bromine trifluoride, and a reaction with zinc releases explosive hydrogen gas. It has an exothermic reaction with water, and when heated to decomposition it emits toxic fumes of chlorine. |
| Synonyms | Calcii chloridum dihydricum; calcii chloridum hexahydricum. |
| CAS Number | 7774-34-7 |
| Category | Desiccants; Preservatives; Adsorbentss |
| UNII | M4I0D6VV5M |
| Chemical Name | Calcium chloride hexahydrate |
| Grade | Pharmceutical Excipients |
| Administration route | Infiltration, Intramuscular, Intraocular, Intrathecal, Intravenous, Intravitreal, Ophthalmic, oral, Respiratory(Inhalation) |
| Dosage Form | Injection, Soultion, Injectable, Liposomal, Susupension, Drops, Capsule, Concentrate |
| Stability and Storage Conditions | Calcium chloride is chemically stable; however, it should be protected from moisture. Store in airtight containers in a cool, dry place. |