Penfluridol
Penfluridol, also known as R-16341 and Semap, is long-acting anti-psychotic agent used for maintenance or long-term therapy of schizophrenia and other psychotic disorders. Penfluridol distributes extensively in fatty tissues following oral administration. This depot effect produces a very slow release of drug from the tissues, and results in a very long duration of activity. 3. Penfluridol is extensively metabolized by oxidative N-dealkylation to afford, as isolated metabolites, the beta-glucuronide conjugate of the diphenylbutyric acid derivative A1 and the unconjugated basic piperidine moiety B1.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1638 |
| CAS # | 26864-56-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | Penfluridol; McN-JR-16341; R-16341; McNJR16341; R16341; McN JR 16341; R 16341; Acemap; Semap |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C28H27ClF5NO |
| Exact Mass | 523.1701 |
| Molecular Weight | 523.972 |
| Elemental Analysis | C, 64.18; H, 5.19; Cl, 6.77; F, 18.13; N, 2.67; O, 3.05 |
| IUPAC/Chemical Name | 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol |
| InChi Key | MDLAAYDRRZXJIF-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2 |
| SMILES Code | OC1(C2=CC=C(Cl)C(C(F)(F)F)=C2)CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |