FK-506 (Tacrolimus, Fujimycin, FK506, Prograf, CAS 104987-11-3), >99%

LC Laboratories' Product Number F-4900 - FK-506 (Tacrolimus, Fujimycin, FK506, Prograf), >99% - for research use only. Ascomycin level is less than 0.5%. FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. FK-506 inhibits FKBP activity resulting in an increase in the release of sarcoplasmic reticulum-derived calcium. FK-506 also appears to inhibit Na(+)-Ca2+ exchange. Prolonged exposure of Xenopus A6 cells to FK-506 significantly inhibits aldosterone-stimulated Na+ transport and Na(+)-K(+)-ATPase activity. Unlike rapamycin, which also binds to FK506-binding protein-12, FKBP12 with or without bound FK506 has no effect on rat brain PKC activity in vitro. FK-506 is subject to various Astellas Pharma Inc. patents in the U.S. and certain other countries; not available in some countries; not available to some institutions; not available for some uses.

• Supplier: LC Laboratories
• Product #: F-4900
• Sku #: F-4900_500mg