CDK4/6 Inhibitor IV
Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine inhibitor for Cdk4/cyclin D1 with IC50 values of 1.5 μM and Cdk6/cyclin D1 with IC50 values of 5.6 μM. It exhibits blocking of pRb phosphorylation at Ser780 and Ser795. Cdk4/6 inhibitor IV can suppresses tumor growth in Xenograft mouse model.
| Supplier | BOC Sciences |
|---|---|
| Product # | 359886-84-3 |
| Pricing | Inquire |
| Cas | 359886-84-3 |
| Molecular Weight | 456.6 |
| Molecular Formula | C27H32N6O |
| Canonical SMILES | CCNC1=NC(NC2=CC=C(N(CC3=CC=CC=C3)C=C4)C4=C2)=NC(N[C@H]5CC[C@H](O)CC5)=C1 |