anti-CD19 immunotoxin HD37 (scFv)-PE
This immunotoxin was achieved by conjugating/fusing the Anti-CD19 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Head and neck squamous cell cancer or bladder cancer.
Supplier | Creative Biolabs |
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Product # | AGTO-L047E |
Pricing | Inquiry |
Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
Host | Mouse |
Target | CD19 |
Species Reactivity | Human |