ABT-546
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-135283 |
| CAS # | 212481-66-8 |
| Pricing | inquire |
| Biological Activity | ABT-546 (A-216546) is a potent, highly selective and active endothelin ETA receptor antagonist with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned human endothelin ETA. ABT-546 is >25,000-fold more selective for the ETA receptor than for the ETB receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50 of 0.59 nM and 3 nM, respectively[1]. |
| Synonyms | A-216546 |
| MWt | 532.71 |
| Formula | C₃₀H₄₈N₂O₆ |